SUMOylation regulates the nuclear mobility of CREB binding protein and its association with nuclear bodies in live cells

@inproceedings{Ryan2010SUMOylationRT,
  title={SUMOylation regulates the nuclear mobility of CREB binding protein and its association with nuclear bodies in live cells},
  author={Colm M. Ryan and Karin B. Kindle and Hilary Collins and David M Heery},
  booktitle={Biochemical and biophysical research communications},
  year={2010}
}
The lysine acetyltransferase CREB binding protein (CBP) is required for chromatin modification and transcription at many gene promoters. In fixed cells, a large proportion of CBP colocalises to PML or nuclear bodies. Using live cell imaging, we show here that YFP-tagged CBP expressed in HEK293 cells undergoes gradual accumulation in nuclear bodies, some of which are mobile and migrate towards the nuclear envelope. Deletion of a short lysine-rich domain that contains the major SUMO acceptor… CONTINUE READING

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