SUMOylation regulates the SNF1 protein kinase.

  title={SUMOylation regulates the SNF1 protein kinase.},
  author={Kobi J. Simpson-Lavy and Mark Johnston},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={110 43},
The AMP-activated protein kinase (AMPK) is a major stress sensor of mammalian cells. AMPK's homolog in the yeast Saccharomyces cerevisiae, the SNF1 protein kinase, is a central regulator of carbon metabolism that inhibits the Snf3/Rgt2-Rgt1 glucose sensing pathway and activates genes involved in respiration. We present evidence that glucose induces modification of the Snf1 catalytic subunt of SNF1 with the small ubiquitin-like modifier protein SUMO, catalyzed by the SUMO (E3) ligase Mms21. Our… CONTINUE READING

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