SUMOylation of the lens epithelium-derived growth factor/p75 attenuates its transcriptional activity on the heat shock protein 27 promoter.

@article{Bueno2010SUMOylationOT,
  title={SUMOylation of the lens epithelium-derived growth factor/p75 attenuates its transcriptional activity on the heat shock protein 27 promoter.},
  author={Murilo Tadeu Domingues Bueno and José A. García-Rivera and Jeffrey R. Kugelman and Elisa Garc{\'i}a Morales Huidobro and Germ{\'a}n Rosas-Acosta and Manuel del Llano},
  journal={Journal of molecular biology},
  year={2010},
  volume={399 2},
  pages={
          221-39
        }
}
Lens epithelium-derived growth factor (LEDGF) proteins p75 and p52 are transcriptional coactivators that connect sequence-specific activators to the basal transcription machinery. We have found that these proteins are posttranslationally modified by SUMO (small ubiquitin-like modifier)-1 and SUMO-3. Three SUMOylation sites, K75, K250, and K254, were mapped on the shared N-terminal region of these molecules, while a fourth site, K364, was identified in the C-terminal part exclusive of LEDGF/p75… CONTINUE READING
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