SUMOylation-disrupting WAS mutation converts WASp from a transcriptional activator to a repressor of NF-κB response genes in T cells.

@article{Sarkar2015SUMOylationdisruptingWM,
  title={SUMOylation-disrupting WAS mutation converts WASp from a transcriptional activator to a repressor of NF-κB response genes in T cells.},
  author={Koustav Sarkar and Sanjoy Sadhukhan and Seong-Su Han and Yatin M Vyas},
  journal={Blood},
  year={2015},
  volume={126 14},
  pages={1670-82}
}
In Wiskott-Aldrich syndrome (WAS), immunodeficiency and autoimmunity often comanifest, yet how WAS mutations misregulate chromatin-signaling in Thelper (TH) cells favoring development of auto-inflammation over protective immunity is unclear. Previously, we identified an essential promoter-specific, coactivator role of nuclear-WASp in TH1 gene transcription. Here we identify small ubiquitin-related modifier (SUMO)ylation as a novel posttranslational modification of WASp, impairment of which… CONTINUE READING

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