SUMO1 attenuates stress-induced ROS generation by inhibiting NADPH oxidase 2.

@article{Kim2011SUMO1AS,
  title={SUMO1 attenuates stress-induced ROS generation by inhibiting NADPH oxidase 2.},
  author={Hyun Jung Kim and Jiwon Yun and Jiyoung Lee and Hyunkyung Hong and Jaeho Jeong and Eunhee Kim and Yun Soo Bae and Kong-Joo Lee},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={410 3},
  pages={555-62}
}
Small ubiquitin-like modifier 1 (SUMO1) is a member of the superfamily of ubiquitin-like proteins. Despite its structural similarity with ubiquitin, SUMO1 does not seem to play any role in protein degradation and its precise biological function is poorly understood. During our studies on heat-shock responses, we found that heat-shock stress increased SUMO1 conjugation in a dose-dependent manner. Intriguingly, SUMO1 conjugation resulted in decrease of intracellular ROS generation and protection… CONTINUE READING
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