SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase

@article{Pfander2005SUMOmodifiedPR,
  title={SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase},
  author={B. Pfander and George-Lucian Moldovan and M. Sacher and Carsten Hoege and S. Jentsch},
  journal={Nature},
  year={2005},
  volume={436},
  pages={428-433}
}
Damaged DNA, if not repaired before replication, can lead to replication fork stalling and genomic instability; however, cells can switch to different damage bypass modes that permit replication across lesions. Two main bypasses are controlled by ubiquitin modification of proliferating cell nuclear antigen (PCNA), a homotrimeric DNA-encircling protein that functions as a polymerase processivity factor and regulator of replication-linked functions. Upon DNA damage, PCNA is modified at the… Expand
Role of SUMO modification of human PCNA at stalled replication fork
Sumoylation of PCNA: Wrestling with recombination at stalled replication forks.
PCNA modifications for regulation of post-replication repair pathways.
Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis
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