SUMO modification regulates MafB-driven macrophage differentiation by enabling Myb-dependent transcriptional repression.

@article{Tillmanns2007SUMOMR,
  title={SUMO modification regulates MafB-driven macrophage differentiation by enabling Myb-dependent transcriptional repression.},
  author={Silke Tillmanns and Claas Otto and Ellis Jaffray and Camille Du Roure and Youssef Bakri and Laurent Vanhille and Sandrine Sarrazin and Ronald Thomas Hay and Michael H Sieweke},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 15},
  pages={5554-64}
}
During the execution of differentiation programs, lineage-specific transcription factors are in competition with antagonistic factors that drive progenitor proliferation. Thus, the myeloid transcription factor MafB promotes macrophage differentiation of myeloid progenitors, but a constitutively active Myb transcription factor (v-Myb) can maintain proliferation and block differentiation. Little is known, however, about the regulatory mechanisms that control such competing activities. Here we… CONTINUE READING
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