SUMO modification of the Ets-related transcription factor ERM inhibits its transcriptional activity.

@article{Degerny2005SUMOMO,
  title={SUMO modification of the Ets-related transcription factor ERM inhibits its transcriptional activity.},
  author={Cindy Degerny and Didier Mont{\'e} and Claude Beaudoin and Ellis Jaffray and Laurence Portois and Ron T. Hay and Yvan de Launoit and J l Baert},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 26},
  pages={24330-8}
}
A variety of transcription factors are post-translationally modified by SUMO, a 97-residue ubiquitin-like protein bound covalently to the targeted lysine. Here we describe SUMO modification of the Ets family member ERM at positions 89, 263, 293, and 350. To investigate how SUMO modification affects the function of ERM, Ets-responsive intercellular adhesion molecule 1 (ICAM-1) and E74 reporter plasmids were employed to demonstrate that SUMO modification causes inhibition of ERM-dependent… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
17 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…