SUMO modification of Sam68 enhances its ability to repress cyclin D1 expression and inhibits its ability to induce apoptosis

@article{Babic2006SUMOMO,
  title={SUMO modification of Sam68 enhances its ability to repress cyclin D1 expression and inhibits its ability to induce apoptosis},
  author={Ivan Babic and Elizabeth Cherry and Donald J. Fujita},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={4955-4964}
}
Sam68 (Src associated in mitosis; 68 kDa) is an RNA-binding protein and substrate of Src family kinases. It is thought to play a role in cell cycle progression. Overexpression of Sam68 in fibroblasts was reported to have two separable functions dependent on its ability to bind RNA — cell cycle arrest or the induction of apoptosis. Post-translational modification with SUMO (small ubiquitin-like modifier) is common to many transcription factors and can regulate protein localization, stability and… CONTINUE READING
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Referenced Papers

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Showing 1-4 of 4 references

Genes Dev 15: 3053–3058

  • PK 6040–6050.Jackson
  • Johnson ES
  • 2001
Highly Influential
5 Excerpts

Mol Cell Biol 20: 6114–6126

  • AW Cochrane
  • Desterro JM, Rodriguez MS, Hay RT. (1998). Mol…
  • 2000

J Biol Chem 272: 3129–3132

  • F. Schweighoffer
  • Chen TP, Boisvert FM, Bazett-Jones DP, Richard S…
  • 1997

Genes Dev 8: 465–480

  • M Avigan
  • Fumagalli S, Totty NF, Hsuan JJ, Courtneidge SA…
  • 1994

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