SUMO-1 modification of the Wilms' tumor suppressor WT1.

@article{Smolen2004SUMO1MO,
  title={SUMO-1 modification of the Wilms' tumor suppressor WT1.},
  author={Gromoslaw A. Smolen and Maria T Vassileva and Julie M. Wells and Michael J Matunis and Daniel A. Haber},
  journal={Cancer research},
  year={2004},
  volume={64 21},
  pages={7846-51}
}
SUMO-1 conjugation modulates numerous cellular functions, including the subnuclear localization of its target proteins. The WT1 tumor suppressor encodes a four-zinc finger protein with distinct splicing isoforms. WT1(-KTS), encoding uninterrupted zinc fingers, functions as a transcription factor and has a diffusely nuclear distribution; WT1(+KTS), with an insertion of three amino acids (KTS) between zinc fingers three and four, localizes to discrete nuclear speckles, the function of which is… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

Similar Papers

Loading similar papers…