SUMO-1 modification of the Wilms' tumor suppressor WT1.

  title={SUMO-1 modification of the Wilms' tumor suppressor WT1.},
  author={Gromoslaw A. Smolen and Maria T Vassileva and Julie M. Wells and Michael J Matunis and Daniel A. Haber},
  journal={Cancer research},
  volume={64 21},
SUMO-1 conjugation modulates numerous cellular functions, including the subnuclear localization of its target proteins. The WT1 tumor suppressor encodes a four-zinc finger protein with distinct splicing isoforms. WT1(-KTS), encoding uninterrupted zinc fingers, functions as a transcription factor and has a diffusely nuclear distribution; WT1(+KTS), with an insertion of three amino acids (KTS) between zinc fingers three and four, localizes to discrete nuclear speckles, the function of which is… CONTINUE READING


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