SUMO-1: Ubiquitin gains weight.

  title={SUMO-1: Ubiquitin gains weight.},
  author={Paul D R Johnson and Mark Hochstrasser},
  journal={Trends in cell biology},
  volume={7 10},
The highly conserved ubiquitin polypeptide functions by covalently modifying other proteins. This modification has a well-established role in facilitating substrate degradation by the proteasome and can regulate some proteins by ways other than targeting them to the proteasome. It has now emerged that proteins bearing only distant similarity to ubiquitin can also be attached to specific proteins. The consequences of most of these modifications are not yet understood. However, two recent papers… CONTINUE READING

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