SUMO: of branched proteins and nuclear bodies

@article{Seeler2001SUMOOB,
  title={SUMO: of branched proteins and nuclear bodies},
  author={J Seeler and Anne Dejean},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={7243-7249}
}
SUMO belongs to a growing number of ubiquitin-like proteins that covalently modify their target proteins. Although some evidence supports a role of SUMO modification in regulating protein stability, most studied examples support a model by which SUMO alters the interaction properties of its targets, often affecting their subcellular localization behavior. Examination of the PML nuclear bodies, whose principal components are SUMO-modified, has revealed this modification to be essential for their… CONTINUE READING

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