SUMO: a history of modification.

  title={SUMO: a history of modification.},
  author={Ronald Thomas Hay},
  journal={Molecular cell},
  volume={18 1},
The small ubiquitin-like modifier (SUMO) is covalently linked to a variety of proteins and is deconjugated by SUMO-specific proteases. A characteristic of SUMO modification is that the biological consequences of conjugation do not appear proportionate to the small fraction of substrate that is modified. SUMO conjugation appears to alter the long-term fate of the modified protein even though the SUMO may be rapidly deconjugated. Thus an unmodified protein with a history of SUMO modification may… CONTINUE READING
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