SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation.

  title={SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation.},
  author={Xingbin Ai and Toshio Kitazawa and Anh-Tri Do and Marion Kusche-Gullberg and Patricia A. Labosky and Charles P. Emerson},
  volume={134 18},
Heparan sulfate (HS) plays an essential role in extracellular signaling during development. Biochemical studies have established that HS binding to ligands and receptors is regulated by the fine 6-O-sulfated structure of HS; however, mechanisms that control sulfated HS structure and associated signaling functions in vivo are not known. Extracellular HS 6-O-endosulfatases, SULF1 and SULF2, are candidate enzymatic regulators of HS 6-O-sulfated structure and modulate HS-dependent signaling. To… CONTINUE READING
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