SU11248 (sunitinib) directly inhibits the activity of mammalian 5'-AMP-activated protein kinase (AMPK).

@article{Laderoute2010SU11248D,
  title={SU11248 (sunitinib) directly inhibits the activity of mammalian 5'-AMP-activated protein kinase (AMPK).},
  author={Keith R. Laderoute and Joy M Calaoagan and Peter B. Madrid and Anthony E. Klon and Paula J Ehrlich},
  journal={Cancer biology & therapy},
  year={2010},
  volume={10 1},
  pages={68-76}
}
AMPK has been termed the fuel sensor of mammalian cells because it directly responds to the depletion of the fuel molecule ATP. In previous work, we found that AMPK is strongly activated by tumor-like hypoxia and glucose deprivation, independently of the oxygen response system associated with HIF-1. We also observed high levels of AMPK activity in tumor cells in vivo, using different model tumors. These findings suggested the hypothesis that modulation of AMPK activity could have therapeutic… CONTINUE READING

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