SU-840, a novel synthetic flavonoid derivative of sophoradin, with potent gastroprotective and ulcer healing activity.

@article{Brzozowski1998SU840AN,
  title={SU-840, a novel synthetic flavonoid derivative of sophoradin, with potent gastroprotective and ulcer healing activity.},
  author={Tomasz Brzozowski and Stanisław Jan Konturek and Sławomir Kwiecień and Robert Pajdo and Danuta Drozdowicz and Zbigniew Śliwowski and Masami Muramatsu},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={1998},
  volume={49 1},
  pages={83-98}
}
Flavonois derived from sophoradine are known to exhibit gastroprotective and ulcer healing properties but the mechanism of these actions are not fully explained. In this study we determined the effect of novel flavonoid derivative of sophoradin, SU-840, on gastric secretion, acute gastric lesions induced by acid-independent (100% ethanol) or acid-dependent ulcerogens (acidified aspirin (ASA) and stress) and on the healing of chronic gastric ulcers in rats. The number and area of gastric lesions… CONTINUE READING