STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES

@article{Mccarty1946STUDIESOT,
  title={STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES},
  author={Maclyn Mccarty and Oswald T. Avery},
  journal={The Journal of Experimental Medicine},
  year={1946},
  volume={83},
  pages={89 - 96}
}
It has been shown that extremely minute amounts of purified preparations of desoxyribonuclease are capable of bringing about the complete and irreversible inactivation of the transforming substance of Pneumococcus Type III. The significance of the effect of the enzyme, and its bearing on the chemical nature of the transforming substance, together with certain considerations concerning the biological specificity of desoxyribonucleic acids in general, are discussed. 
The nucleic acid fractions of a strain of Streptococcus faecalis.
SUMMARY: The Schmidt & Thannhauser (1945) procedure was applied to the nucleic acid fractions of Streptococcus faecalis. A part of the deoxypentose nucleic acid was differentiated as being insoluble
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A method for the quantitative isolation of pure highly polymerized DNA from Serratia marcescens, based on Kirby's phenol extraction procedure, has been developed and 6-Methyl-aminopurine was found in the DNA of Serratian organism.
[The research-study of pneumococci transformation in the laboratory, and the rise of bacterial genetics and molecular biology].
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The early rise and development of bacterial genetics and molecular biology is described, which carried the information necessary to direct all biochemical-cellular activities and self-replications.
The isolation of deoxyribonucleic acid from virulent and avirulent strains of Haemophilus pertussis.
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This finding gives further evidence of the differences in biological properties of virulent and avirulent strains such as agglutinability by type-specific serum, precipitability by aluminium phosphate, and solubility in bile and sodium hydroxide.
THE FINE STRUCTURE OF DIPLOCOCCUS PNEUMONIAE
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The fine structure of an unencapsulated strain of Diplococcus pneumoniae is described and an intracytoplasmic membrane system which appears to be an extension of septa of dividing bacteria is discussed.
Variation in Pigment Production in Staphylococcus aureus
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The present study deals with an attempt to induce transformation of a white Sfaphylocuccus uureus into a chromogenic type, and results indicate that the substance has the characteristics of a desoxyribonucleic acid.
Transformability of Haemop hilus influenzae
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A method is described for the preparation of highly competent (transformable) bacteria of Haemophilus injuenzae and transformation frequencies close to 5 yo have been obtained.
RELEASE OF GENETIC TRANSFORMING AGENT FROM PNEUMO- COCCAL CULTURES DURING GROWTH AND DISINTEGRATION* BY ELENA OTTOLENGHI,~ ProD., AND ROLLIN D. HOTCHKISS, ProD
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The present communication deals with the nature of the process of release of genetically active material from streptomycintreated and from untreated growing pneumococcal cultures.
RECIPROCAL CAPSULAR TRANSFORMATIONS OF PNEUMOCOCCI
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One of the interesting questions concerning bacterial trainsformations is the fate of the endogenous deoxyribonucleic acid (DNA) present in the host bacterium about to produce genetically transformed
DETERMINATION OF TYPE IN CAPSULATED TRANSFORMANTS OF PNEUMOCOCCUS BY THE GENOME OF NON-CAPSULATED DONOR AND RECIPIENT STRAINS
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The most striking result was the production of both IIS and VIIIS transformants by the action of extracts of both VIIIR strains applied to cells of II-RB, suggesting that the determination of capsular type in pneumococcus does not depend on single allelomorphic genes.
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