STUDIES ON HYPOALBUMINEMIA PRODUCED BY PROTEIN-DEFICIENT DIETS : I. HYPOALBUMINEMIA AS A QUANTITATIVE MEASURE OF TISSUE PROTEIN DEPLETION.

@article{Sachar1942STUDIESOH,
  title={STUDIES ON HYPOALBUMINEMIA PRODUCED BY PROTEIN-DEFICIENT DIETS : I. HYPOALBUMINEMIA AS A QUANTITATIVE MEASURE OF TISSUE PROTEIN DEPLETION.},
  author={Leo A. Sachar and Abraham Horvitz and Robert Elman},
  journal={The Journal of experimental medicine},
  year={1942},
  volume={75 4},
  pages={
          453-9
        }
}
In five dogs placed on a protein-poor diet for 3 weeks, the decline in total circulating plasma albumin was a small (3 per cent) but relatively constant part of the total nitrogen lost. These data together with observations on dogs by others indicate that there is a constant relationship or partition in the loss (or gain) between plasma albumin and total body protein induced by diet. Based on this relationship a formula is developed for estimating the degree of total tissue protein deficiency… Expand
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