STUDIES OF STREPTOCOCCAL FIBRINOLYSIS. II. THE INHIBITION OF STREPTOCOCCAL FIBRINOLYSIS BY ANTIFIBRINOLYSIN AND ANTIPROTEASE.
@article{Kaplan1946STUDIESOS,
title={STUDIES OF STREPTOCOCCAL FIBRINOLYSIS. II. THE INHIBITION OF STREPTOCOCCAL FIBRINOLYSIS BY ANTIFIBRINOLYSIN AND ANTIPROTEASE.},
author={Melvin H. Kaplan},
journal={The Journal of clinical investigation},
year={1946},
volume={25 3},
pages={
337-46
}
}Figures and Tables from this paper
18 Citations
STUDIES OF STREPTOCOCCAL FIBRINOLYSIS
- Medicine
- 2013
The substitution of a clot formed from fibrinogen and thrombin for fresh plasma makes the test readily adaptable to the study of sera in a routine manner and the definition of the unit of measure should result in more uniformity in reporting data concerning antifibrinolysin.
STUDIES OF STREPTOCOCCAL FIBRINOLYSIS. IV. CLINICAL APPLICATION OF A QUANTITATIVE ANTIFIBRINOLYSIN TEST.
- MedicineThe Journal of clinical investigation
- 1946
Artificially induced pulmonary embolism in dogs.
- MedicineArchives of surgery
- 1962
The earliest effective approach to thromboembolic disease made use of heparin and the coumarin drugs, but their role in the actual prevention of recurrent thrombosis is subject to question in many series because of the lack of control clinical material.
Therapy of retinal vein occlusion. Use of fibrinolysin and anticoagulants.
- MedicineAmerican journal of ophthalmology
- 1961
Effects of Intravenous Administration of Fibrinolysin (Plasmin) in Man
- MedicineCirculation
- 1959
The effects of intravenous administration of purified fibrinolysin in man are reported, with special emphasis upon systemic toxicity and alterations in clotting factors and fibralelytic activity.
Thrombolysis with fibrinolysin (plasmin)-new therapeutic approach to thromboembolism.
- MedicineJournal of the American Medical Association
- 1958
Fifty-two patients with various forms of thromboembolic disease were treated by intravenous infusions of a preparation of fibrinolysin in dosages up to 90,000 fibrinogen-thrombin units (FU), and 92% of the recipients manifested an enhanced plasmafibrinolytic activity at some time after the infusion.
Die Klinik und Chemie der Proteinasen des menschlichen und tierischen Organismus, ihre besondere Bedeutung in seinen Abwehrleistungen und in der klinischen Diagnostik
- Philosophy
- 1951
Proteolytische Fermente sind ein ubiquitarer Bestandteil des Fermentsystems der menschlichen Zelle. Sie dienen zum Auf- und Abbau von Zelleiweis, zum Aufschlus der Nahrungsproteine im…
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STUDIES ON STREPTOCOCCAL FIBRINOLYSIS
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It was demonstrated that strains of streptococci which produced large amounts of fibrinolysin were capable of stimulating antifibrinosin formation in patients whereas strains that produced small amounts only occasionally caused antibody formation.
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STREPTOCOCCAL FIBRINOLYSIS: A PROTEOLYTIC REACTION DUE TO A SERUM ENZYME ACTIVATED BY STREPTOCOCCAL FIBRINOLYSIN
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It is suggested that lysin factor exists in serum or plasma as a zymogen, and that it is activated by fibrinolysin, a kinase, in a manner similar to the activation of trypsinogen by enterokinase or the mold kinase of Kunitz (1938).
CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. I. THE CHARACTERIZATION OF THE PROTEIN FRACTIONS OF HUMAN PLASMA.
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In the case of the products from human plasma, it seemed most appropriate to employ not only clinical but also physical chemical methods of control-procedures which had been of value in the development of these products.
INHIBITION OF β HEMOLYTIC STREPTOCOCCI FIBRINOLYSIN BY TRYPSIN INHIBITOR (ANTIPROTEASE)
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Crystalline "trypsin-inhibitor" of pancreatic origin and the antitrypsin of soybean origin completely inhibit the fibrinolytic activity of cultures of β hemolytic streptococci, of filtrates of such…
Nature and Role of the Lytic Factor in Hemolytic Streptococcal Fibrinolysis.∗
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Summary The lytic factor of Milstone and the globulin substance may both be activated by certain organic solvents to yield a true proteolytic enzyme. Both lytic factor and globulin substance are…
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THE ANTIPROTEOLYTIC ACTIVITY OF SERUM
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- 1943
The experimental results indicate that the products of protein hydrolysis in the intestine and parenterally are an important factor in the antiproteolytic activity of the serum and that antibodies to trypsin are not an importantfactor.