STUDIES IN CARDIAC NECROSIS. 3. METABOLIC EFFECTS OF SYMPATHOMIMETIC AMINES PRODUCING CARDIAC LESIONS.

@article{Rosenblum1965STUDIESIC,
  title={STUDIES IN CARDIAC NECROSIS. 3. METABOLIC EFFECTS OF SYMPATHOMIMETIC AMINES PRODUCING CARDIAC LESIONS.},
  author={Ira Rosenblum and Arnold J. Wohl and Arthur A. Stein},
  journal={Toxicology and applied pharmacology},
  year={1965},
  volume={7},
  pages={
          344-51
        }
}
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20 Citations

20 Citations

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The chronic subcutaneous administration of isoproterenol to neonatal and young male and female rats resulted in statistically significant reductions of the norepinephrine concentrations of the heart…
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References

SHOWING 1-10 OF 20 REFERENCES
STUDIES IN CARDIAC NECROSIS. II. CARDIOVASCULAR EFFECTS OF SYMPATHOMIMETIC AMINES PRODUCING CARDIAC LESIONS.
STUDIES IN CARDIAC NECROSIS. I. PRODUCTION OF CARDIAC LESIONS WITH SYMPATHOMIMETIC AMINES.
Plasma free fatty acid and blood glucose responses to analogues of norepinephrine in man
TLDR
The observations suggest that, in derivatives of phenylethylamine, hydroxyl substitution at the pura position and on the @-carbon and the presence of a primary or secondary amine structure are associated with the potent ability to elicit elevations of FFA in man.
The effect of amines on the blood sugar of the rat.
TLDR
An analysis of the data indicates that epinephrine combines by means of its nitrogen atom, and produces glycogenolysis after this combination through the functional phenolic group.
Some similar effects after large doses of catecholamines and myocardial infarction in dogs.
Myocardial removal of free fatty acids under normal pathological conditions.
TLDR
Myocardial arteriovenous difference in free fatty acids (FFA) and coronary flow was determined in dogs under morphine-chloralose anesthesia and a different relationship suggested itself in hypothyroid animals.
Fatty acid analysis of brain tumors by gas phase chromatography.
TLDR
Brain tissue is characterized by a high lipid content in which there are 3 major classes: neutral lipids, glycerophospholipids, and sphingolipid, and it is apparent that the fatty acid pattern for precise areas of brain tissue would be an excellent screening procedure for localized or generalized lipid disturbance.
Free fatty acid concentration and composition in arterial blood.
The effect of the administration of norepinephrine, glucose and insulin, pentobarbital, and Hypertensin on the arterial concentration and composition of plasma free fatty acids (FFA) has been studied…
Some hormonal effects on uptake of free fatty acids by the liver
TLDR
The uptake of free fatty acids by the liver was determined in dogs by measuring the portal-hepatic difference in FFA and liver plasma flow and it is not known, whether the changes in hepatic uptake of FFA are due indirectly to the influence of altered systemic FFA levels on the liver, or to a direct effect of the hormones on the Liver.
The nature of the epinephrine-induced hyperlipidemia in dogs and its modification by glucose.
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