STRETCH‐ACTIVATED CHANNELS IN STRETCH‐INDUCED MUSCLE DAMAGE: ROLE IN MUSCULAR DYSTROPHY

@article{Yeung2004STRETCHACTIVATEDCI,
  title={STRETCH‐ACTIVATED CHANNELS IN STRETCH‐INDUCED MUSCLE DAMAGE: ROLE IN MUSCULAR DYSTROPHY},
  author={Ella W Yeung and David G Allen},
  journal={Clinical and Experimental Pharmacology and Physiology},
  year={2004},
  volume={31}
}
  • E. Yeung, David G Allen
  • Published 2004
  • Chemistry, Medicine
  • Clinical and Experimental Pharmacology and Physiology
1. Stretch‐induced muscle injury results in the damage that causes reduced force and increased membrane permeability. This muscle damage is caused, in part, by ionic entry through stretch‐activated channels and blocking these channels with Gd3+ or streptomycin reduces the force deficit associated with damage. 
SKELETAL MUSCLE FUNCTION: ROLE OF IONIC CHANGES IN FATIGUE, DAMAGE AND DISEASE
  • D. Allen
  • Chemistry, Medicine
  • Clinical and experimental pharmacology & physiology
  • 2004
TLDR
The role of early ionic changes in the development of skeletal muscle conditions, including fatigue, can degenerate in some disease conditions and should be considered. Expand
Damage to Skeletal Muscle from Eccentric Exercise
TLDR
Aspects discussed include the decline in active tension, increase in passive tension, shift in length–tension relation, soreness, swelling, and disturbed proprioception. Expand
Mechanisms of exercise-induced muscle damage and fatigue : Intracellular calcium accumulation
Contraction-induced compromise of muscle function and, in the extreme, muscle damage has been linked to loss of Ca2+ homeostasis and resultant sustained elevation of intracellular Ca2+ ([Ca]i).Expand
Cellular mechanism of eccentric-induced muscle injury and its relationship with sarcomere heterogeneity
TLDR
This review will focus on the two main cellular mechanism of muscle cell injury following accustomed eccentric contraction, activation impairment and structural disruption of the sarcomere. Expand
Biological Role of TRPC1 in Myogenesis, Regeneration, and Disease
TLDR
This chapter summarizes the evidence for the regulation of TRPC1 to fulfill specific physiological functions in skeletal muscles. Expand
Inhibition of stretch-activated channels during eccentric muscle contraction attenuates p70S6K activation.
TLDR
Data indicate the necessity of functional SAC for the complete activation of Akt and p70S6K pathway in response to EC, and indicates that inhibition of stretch-activated channels resulted in an attenuation of EC-induced muscle hypertrophy. Expand
Intracellular Ca2+ Signaling in Skeletal Muscle: Decoding a Complex Message
  • E. Chin
  • Chemistry, Medicine
  • Exercise and sport sciences reviews
  • 2010
TLDR
Intracellular calcium (Ca2+) plays an important role in regulating muscle force production, metabolism, and muscle gene expression and it is hypothesized that the precise pattern of Ca2+ oscillations controls the coupling between neural activation, forceproduction, cellular energetics, and gene expression. Expand
Blood flow restriction prevents muscle damage but not protein synthesis signaling following eccentric contractions
TLDR
The present findings suggest that ECC combined with BFR, even at high exercise intensities, may enhance muscle protein synthesis without appreciable muscle fiber damage. Expand
Microfluidic-assisted cyclic mechanical stimulation affects cellular membrane integrity in a human muscular dystrophy in vitro model
Cyclic mechanical stimulation has been found to deeply affect cell behavior in terms of cytoskeleton remodeling, signaling pathway alteration and differential gene expression in several diseases. InExpand
Stretch-activated calcium channel protein TRPC1 is correlated with the different degrees of the dystrophic phenotype in mdx mice.
TLDR
It is suggested that different levels of the stretch-activated calcium channel protein TRPC1 may contribute to the different degrees of the dystrophic phenotype seen in mdx mice. Expand
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SKELETAL MUSCLE FUNCTION: ROLE OF IONIC CHANGES IN FATIGUE, DAMAGE AND DISEASE
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  • Chemistry, Medicine
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