STRA8-deficient spermatocytes initiate, but fail to complete, meiosis and undergo premature chromosome condensation.

@article{Mark2008STRA8deficientSI,
  title={STRA8-deficient spermatocytes initiate, but fail to complete, meiosis and undergo premature chromosome condensation.},
  author={Manuel P. Mark and Hugues Jacobs and Mustapha Oulad-Abdelghani and Christine Dennefeld and Betty F{\'e}ret and Nad{\`e}ge Vernet and C Codreanu and Pierre Chambon and Norbert B. Ghyselinck},
  journal={Journal of cell science},
  year={2008},
  volume={121 Pt 19},
  pages={3233-42}
}
We analysed the phenotypic outcome of a Stra8-null mutation on male meiosis. Because the mutant spermatocytes (1) underwent premeiotic DNA replication, (2) displayed cytological features attesting initiation of recombination and of axial-element assembly, and (3) expressed Spo11 and numerous other meiotic genes, it was concluded that STRA8 is dispensable for meiotic initiation. The few mutant spermatocytes that progressed beyond leptonema showed a prolonged bouquet-stage configuration… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 75 extracted citations

Similar Papers

Loading similar papers…