STRA6-Catalyzed Vitamin A Influx, Efflux, and Exchange

  title={STRA6-Catalyzed Vitamin A Influx, Efflux, and Exchange},
  author={Riki Kawaguchi and Ming Zhong and Miki Kassai and Mariam Ter-Stepanian and Hui Sun},
  journal={The Journal of Membrane Biology},
Vitamin A has diverse biological functions and is essential for human survival. STRA6 is the high-affinity membrane receptor for plasma retinol binding protein (RBP), the principle and specific carrier of vitamin A (retinol) in the blood. It was previously shown that STRA6 couples to lecithin retinol acyltransferase (LRAT) and cellular retinol binding protein I (CRBP-I), but poorly to CRBP-II, for retinol uptake from holo-RBP. STRA6 catalyzes both retinol release from holo-RBP, which is… CONTINUE READING
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