STOP and GO with NO: nitric oxide as a regulator of cell motility in simple brains.

@article{Bicker2005STOPAG,
  title={STOP and GO with NO: nitric oxide as a regulator of cell motility in simple brains.},
  author={Gerd Bicker},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2005},
  volume={27 5},
  pages={495-505}
}
  • Gerd Bicker
  • Published 2005 in
    BioEssays : news and reviews in molecular…
During the formation of the brain, neuronal cell migration and neurite extension are controlled by extracellular guidance cues. Here, I discuss experiments showing that the messenger nitric oxide (NO) is an additional regulator of cell motility. NO is a membrane permeant molecule, which activates soluble guanylyl cyclase (sGC) and leads to the formation of cyclic GMP (cGMP) in target cells. The analysis of specific cells types in invertebrate models such as molluscs, insects and the medicinal… CONTINUE READING
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