STOP Proteins are Responsible for the High Degree of Microtubule Stabilization Observed in Neuronal Cells

@article{Guillaud1998STOPPA,
  title={STOP Proteins are Responsible for the High Degree of  Microtubule Stabilization Observed in Neuronal Cells },
  author={Laurent Guillaud and Christophe Bosc and Anne Fourest-Lieuvin and Eric Denarier and Fabienne Pirollet and Laurence Lafanech{\`e}re and Didier Job},
  journal={The Journal of Cell Biology},
  year={1998},
  volume={142},
  pages={167 - 179}
}
Neuronal differentiation and function require extensive stabilization of the microtubule cytoskeleton. Neurons contain a large proportion of microtubules that resist the cold and depolymerizing drugs and exhibit slow subunit turnover. The origin of this stabilization is unclear. Here we have examined the role of STOP, a calmodulin-regulated protein previously isolated from cold-stable brain microtubules. We find that neuronal cells express increasing levels of STOP and of STOP variants during… CONTINUE READING