STN1 OB Fold Mutation Alters DNA Binding and Affects Selective Aspects of CST Function

@inproceedings{Bhattacharjee2016STN1OF,
  title={STN1 OB Fold Mutation Alters DNA Binding and Affects Selective Aspects of CST Function},
  author={Anukana Bhattacharjee and Jason Stewart and Mary F. Chaiken and Carolyn M. Price},
  booktitle={PLoS genetics},
  year={2016}
}
Mammalian CST (CTC1-STN1-TEN1) participates in multiple aspects of telomere replication and genome-wide recovery from replication stress. CST resembles Replication Protein A (RPA) in that it binds ssDNA and STN1 and TEN1 are structurally similar to RPA2 and RPA3. Conservation between CTC1 and RPA1 is less apparent. Currently the mechanism underlying CST action is largely unknown. Here we address CST mechanism by using a DNA-binding mutant, (STN1 OB-fold mutant, STN1-OBM) to examine the… CONTINUE READING

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