STK39 is an independent risk factor for male hypertension in Han Chinese.

@article{Chen2012STK39IA,
  title={STK39 is an independent risk factor for male hypertension in Han Chinese.},
  author={Li-yan Chen and Wei-hua Zhao and Wen Tian and Jian Guo and Feng Jiang and Li-juan Jin and Yingxian Sun and Kai-Ming Chen and Li-Li An and Guo-Dong Li and Qing Li and Yang Li and Chong Wu and Ling Zhao and Wen-jing Wang and Gu-Yan Zheng and Bing Li and Xue-qi Li and Jian Hu and Xiaoli Tian},
  journal={International journal of cardiology},
  year={2012},
  volume={154 2},
  pages={122-7}
}
BACKGROUND STK39 interacts with OXSR1 and phosphorylates the sodium-chloride co-transporter (SLC12A3), which plays a critical role in regulating the salt/water balance and blood pressure. Here we tested whether STK39, OXSR1, and SLC12A3 genetically contribute to hypertension in the Han Chinese population and how the SNP to SNP or SNP to other risk factors interacts in the pathogenesis of hypertension. METHODS AND RESULTS Eleven tagging SNPs from STK39, OXSR1, and SLC12A3 were selected and… CONTINUE READING