STINGing revelations

  title={STINGing revelations},
  author={Paulina J Strzyz},
  journal={Nature Reviews Molecular Cell Biology},
  • P. Strzyz
  • Published 2019
  • Psychology
  • Nature Reviews Molecular Cell Biology
Four studies provide new insights into the mechanism, functions and regulation of the cGAS–STING pathway. 
No magnesium is needed for binding of the stimulator of interferon genes to cyclic dinucleotides.
It is shown that no Mg atoms are needed for this interaction of STING with CDN; in fact, magnesium can in some cases obstruct the binding of a CDN to STING.
The Trinity of cGAS, TLR9, and ALRs Guardians of the Cellular Galaxy Against Host-Derived Self-DNA
The present review describes the role of ALRs (AIM2), TLR9, and cGAS in recognizing the host cell DNA as a potent damage/danger-associated molecular pattern (DAMP), which moves out to the cytosol from its housing organelles (nucleus and mitochondria) and comes into action to guard the cellular galaxy.


Autophagy induction via STING trafficking is a primordial function of the cGAS pathway
It is reported that cGAMP-induced autophagy is important for the clearance of DNA and viruses in the cytosol and Interestingly, STING from the sea anemone Nematostella vectensis inducesAutophagy but not interferons in response to stimulation by cGamp, which suggests that induction of autophileagy is a primordial function of the cGAS–STING pathway.
Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP
Cryo-electron microscopy structures of full-length STING show that cyclic GMP–AMP induces a half-turn rotation of the ligand-binding domain relative to the transmembrane domain, forming a tetramer and higher-order oligomers for signalling.
Structural basis of STING binding with and phosphorylation by TBK1
Cryo-electron microscopy structure of human TBK1 in complex with cyclic GMP–AMP-bound, full-length chicken STING reveals a binding mode that suggests that STING phosphorylation by TBK 1 requires oligomerization of both proteins.