STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum

@article{Moretti2017STINGSM,
  title={STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum},
  author={Julien Moretti and Soumit Roy and D. Bozec and Jennifer S. Martinez and Jessica R Chapman and B. Ueberheide and D. Lamming and Zhijian J. Chen and T. Horng and G. Yeretssian and D. Green and J. Blander},
  journal={Cell},
  year={2017},
  volume={171},
  pages={809-823.e13}
}
Constitutive cell-autonomous immunity in metazoans predates interferon-inducible immunity and comprises primordial innate defense. Phagocytes mobilize interferon-inducible responses upon engagement of well-characterized signaling pathways by pathogen-associated molecular patterns (PAMPs). The signals controlling deployment of constitutive cell-autonomous responses during infection have remained elusive. Vita-PAMPs denote microbial viability, signaling the danger of cellular exploitation by… Expand
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