STIMULATION OF CELLULAR FUNCTION BY THYMOPENTIN (TP-5) IN THREE AIDS PATIENTS

@article{MascartLemone1983STIMULATIONOC,
  title={STIMULATION OF CELLULAR FUNCTION BY THYMOPENTIN (TP-5) IN THREE AIDS PATIENTS},
  author={Françoise Mascart‐Lemone and Kris Huygen and Nathan Clumeck and Daniel Brenez and Krishna Chaitanya Bolla and Jean Duchateau},
  journal={The Lancet},
  year={1983},
  volume={322},
  pages={735-736}
}
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TLDR
Six hybrid peptides were designed by combining the full-length TP5 with different active fragments of CATH2, and CbTP, the most potent TLR2 agonist among the six hybrid peptide, was effectively screened through in silico analysis and in vitro experiments, showing lower cytotoxicity and increased immunopotentiating activity and physiological stability.
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Virtual screening is used to facilitate drug repurposing against SARS-CoV-2, targeting viral main proteinase and spike protein with 3000 existing drugs, and provides suggestions for prioritizing in vitro and/or in vivo tests of already available compounds.
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Structural changes in S2 domain is vital for viral fusion and entry into host cell and if this process is hindered by targeting the HR1 and CH region then the progression of virus can be stopped.
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TLDR
TP5 is delineated as an immunomodulator that may be a potential drug for the treatment of UC by exerting a protective effect on DSS-induced colitis by triggering the production of IL-22 in both innate and adaptive lymphocytes.
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TLDR
TP5-MA showed well preserved biological characteristics and significant longer elimination half-life in human plasma compared with TP5, and the protracted immunomodulating effect was confirmed by the immunodepression rat model with subcutaneous injections of TP5- MA.
Enhancing of anti‐viral activity against HIV‐1 by stimulation of CD8+ T cells with thymic peptides
TLDR
The data demonstrate that CD8+ T cells are additionally activated by a mixture of TP, which means that the production of HIV‐1 neutralizing CD8 factors can be enhanced.
Preliminary results on clinical and immunological effects of thymus hormone preparations in AIDS
TLDR
Clinical trials with thymic compounds aiming at restoring the immune dysfunctions and endocrine function impairments among patients with HIV infection will be reviewed.
Immunologic effects of long-term thymopentin treatment in patients with HIV-induced lymphadenopathy syndrome.
TLDR
Significant increases in circulating T4 cells and a reduction of PWM-induced immunoglobulin suppression were noted in the 21 patients who completed the trial, and addition of thymopentin to the in vitro cultures improved the PWM response of T and B cells.
The Immunopathogenesis of AIDS
In 1981, a handful of cases of an apparently new acquired immune deficiency syndrome were reported to the Centers for Disease Control in Atlanta1,2. At that time it was assumed that the profound
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