STIM1 enhances SR Ca2+ content through binding phospholamban in rat ventricular myocytes.

@article{Zhao2015STIM1ES,
  title={STIM1 enhances SR Ca2+ content through binding phospholamban in rat ventricular myocytes.},
  author={Guiling Zhao and Tianyu Li and Didier X. P. Brochet and Paul B Rosenberg and W. Jonathan Lederer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 34},
  pages={E4792-801}
}
In ventricular myocytes, the physiological function of stromal interaction molecule 1 (STIM1), an endo/sarcoplasmic reticulum (ER/SR) Ca(2+) sensor, is unclear with respect to its cellular localization, its Ca(2+)-dependent mobilization, and its action on Ca(2+) signaling. Confocal microscopy was used to measure Ca(2+) signaling and to track the cellular… CONTINUE READING