STIM1 converts TRPC1 from a receptor-operated to a store-operated channel: moving TRPC1 in and out of lipid rafts.

@article{Alicia2008STIM1CT,
  title={STIM1 converts TRPC1 from a receptor-operated to a store-operated channel: moving TRPC1 in and out of lipid rafts.},
  author={Sampieri Alicia and Zepeda Ang{\'e}lica and Salda{\~n}a Carlos and Salgado Alfonso and Luis Vaca},
  journal={Cell calcium},
  year={2008},
  volume={44 5},
  pages={479-91}
}
While the role of members from the TRPC family of channels as receptor-operated channels (ROC) is well established and supported by numerous studies, the role of this family of channels as store-operated channels (SOC) has been the focus of a heated controversy over the last few years. In the present study, we have explored the modulation of STIM1 on human TRPC1 channel. We show that the association of STIM1 to TRPC1 favors the insertion of TRPC1 into lipid rafts, where TRPC1 functions as a SOC… CONTINUE READING
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