STIM1- and Orai1-dependent store-operated calcium entry regulates human myoblast differentiation.

@article{Darbellay2009STIM1AO,
  title={STIM1- and Orai1-dependent store-operated calcium entry regulates human myoblast differentiation.},
  author={Basile Darbellay and Serge Arnaudeau and Stephane Koenig and H{\'e}l{\`e}ne Jousset and Charles Roland Bader and Nicolas Demaurex and Laurent Bernheim},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 8},
  pages={5370-80}
}
Our previous work on human myoblasts suggested that a hyperpolarization followed by a rise in [Ca(2+)](in) involving store-operated Ca(2+) entry (SOCE) channels induced myoblast differentiation. Advances in the understanding of the SOCE pathway led us to examine more precisely its role in post-natal human myoblast differentiation. We found that SOCE orchestrated by STIM1, the endoplasmic reticulum Ca(2+) sensor activating Orai Ca(2+) channels, is crucial. Silencing STIM1, Orai1, or Orai3… CONTINUE READING

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