STIM1 Overexpression Promotes Colorectal Cancer Progression, Cell Motility and COX-2 Expression

Abstract

Tumor metastasis is the major cause of death among cancer patients, with >90% of cancer-related death attributable to the spreading of metastatic cells to secondary organs. Store-operated Ca2+ entry (SOCE) is the predominant Ca2+ entry mechanism in most cancer cells, and stromal interaction molecule 1 (STIM1) is the endoplasmic reticulum (ER) Ca2+ sensor… (More)
DOI: 10.1038/onc.2014.366

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