STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.

Abstract

Highly efficient mechanisms regulate intracellular calcium (Ca2+) levels. The recent discovery of new components linking intracellular Ca2+ stores to plasma membrane Ca2+ entry channels has brought new insight into the understanding of Ca2+ homeostasis. Stromal interaction molecule 1 (STIM1) was identified as a Ca2+ sensor essential for Ca2+ store depletion-triggered Ca2+ influx. Orai1 was recognized as being an essential component for the Ca2+ release-activated Ca2+ (CRAC) channel. Together, these proteins participate in store-operated Ca2+ channel function. Defective regulation of intracellular Ca2+ is a hallmark of several diseases. In this review, we focus on Ca2+ regulation by the STIM1/Orai1 pathway and review evidence that implicates STIM1/Orai1 in several pathological conditions including cardiovascular and pulmonary diseases, among others.

Cite this paper

@article{Giachini2011STIM1Orai1mediatedSC, title={STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.}, author={Fernanca R C Giachini and Victor Vitorino Lima and Johanna L Hannan and Fernando Silva Carneiro and Robert Clinton Webb and Rita C A Tostes}, journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas}, year={2011}, volume={44 11}, pages={1080-7} }