STIM1/Orai1-mediated SOCE: current perspectives and potential roles in cardiac function and pathology.

  title={STIM1/Orai1-mediated SOCE: current perspectives and potential roles in cardiac function and pathology.},
  author={Helen E Collins and Xiaoyuan Zhu-Mauldin and Richard B. Marchase and John C. Chatham},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={305 4},
Store-operated Ca²⁺ entry (SOCE) is critical for Ca²⁺ signaling in nonexcitable cells; however, its role in the regulation of cardiomyocyte Ca²⁺ homeostasis has only recently been investigated. The increased understanding of the role of stromal interaction molecule 1 (STIM1) in regulating SOCE combined with recent studies demonstrating the presence of STIM1 in cardiomyocytes provides support that this pathway co-exists in the heart with the more widely recognized Ca²⁺ handling pathways… 

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