STIL Microcephaly Mutations Interfere with APC/C-Mediated Degradation and Cause Centriole Amplification

@article{Arquint2014STILMM,
  title={STIL Microcephaly Mutations Interfere with APC/C-Mediated Degradation and Cause Centriole Amplification},
  author={Christian Arquint and Erich A. Nigg},
  journal={Current Biology},
  year={2014},
  volume={24},
  pages={351-360}
}
BACKGROUND STIL is a centriole duplication factor that localizes to the procentriolar cartwheel region, and mutations in STIL are associated with autosomal recessive primary microcephaly (MCPH). Excess STIL triggers centriole amplification, raising the question of how STIL levels are regulated. RESULTS Using fluorescence time-lapse imaging, we identified a two-step process that culminates in the elimination of STIL at the end of mitosis. First, at nuclear envelope breakdown, Cdk1 triggers the… CONTINUE READING
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