STEIN: A simple toxicity and efficacy interval design for seamless phase I/II clinical trials.


Seamless phase I/II dose-finding trials are attracting increasing attention nowadays in early-phase drug development for oncology. Most existing phase I/II dose-finding methods use sophisticated yet untestable models to quantify dose-toxicity and dose-efficacy relationships, which always renders them difficult to implement in practice. To simplify the… (More)
DOI: 10.1002/sim.7428


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