• Medicine
  • Published in Anticancer research 2007

STEALTH liposomal CKD-602, a topoisomerase I inhibitor, improves the therapeutic index in human tumor xenograft models.

@article{Yu2007STEALTHLC,
  title={STEALTH liposomal CKD-602, a topoisomerase I inhibitor, improves the therapeutic index in human tumor xenograft models.},
  author={Ning Y. Yu and Colleen M. Conway and Rhoneil L.S. Pena and Joy Y. Chen},
  journal={Anticancer research},
  year={2007},
  volume={27 4B},
  pages={
          2541-5
        }
}
BACKGROUND CKD-602, a topoisomerase I inhibitor, has antitumor activity in a broad spectrum of tumor types. STEALTH liposomal CKD-602 (S-CKD602) prolongs circulation of CKD-602 in plasma, increases drug exposure in tumors and improves efficacy compared with free drug. MATERIALS AND METHODS Different dosing regimens of S-CKD602, free CKD-602 and topotecan were compared for antitumor activity in female athymic nude mice bearing human A375 melanoma, ES-2 ovarian, H82 SCLC or HT-29 colon tumor… CONTINUE READING

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