STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer.

@article{Pea2013STC1EB,
  title={STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer.},
  author={Cristina Pe{\~n}a and Mar{\'i}a Virtudes C{\'e}spedes and Maja Bradic Lindh and Sara Kiflemariam and Artur Mezheyeuski and Per-Henrik D Edqvist and Christina H{\"a}ggl{\"o}f and Helgi Birgisson and Linda Bojmar and Karin Jirstr{\"o}m and Per Sandstr{\"o}m and Eleonor Olsson and Srinivas Veerla and Alberto Gallardo and Tobias Sj{\"o}blom and Andy C.-M. Chang and Roger R. Reddel and Ram{\'o}n Mangues and Martin Augsten and Arne Ostman},
  journal={Cancer research},
  year={2013},
  volume={73 4},
  pages={
          1287-97
        }
}
Platelet-derived growth factor (PDGF) receptor signaling is a major functional determinant of cancer-associated fibroblasts (CAF). Elevated expression of PDGF receptors on stromal CAFs is associated with metastasis and poor prognosis, but mechanism(s) that underlie these connections are not understood. Here, we report the identification of the secreted glycoprotein stanniocalcin-1 (STC1) as a mediator of metastasis by PDGF receptor function in the setting of colorectal cancer. PDGF-stimulated… 
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113 Citations

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Organ Specificity and Heterogeneity of Cancer-Associated Fibroblasts in Colorectal Cancer
TLDR
This review attempts to describe cellular features of colorectal CAFs with an emphasis on their heterogeneity and functional diversity in terms of their function, pathogenic role and cellular origin.
STC1 expression is associated with tumor growth and metastasis in breast cancer
TLDR
This is the first study to show definitively that STC1 plays an oncogenic role in breast cancer, and indicates thatSTC1 could be a potential therapeutic target for treatment of breast cancer patients.
Pharmacological Inhibition and Genetic Knockdown of BCL9 Modulate the Cellular Landscape of Cancer-Associated Fibroblasts in the Tumor-Immune Microenvironment of Colorectal Cancer
TLDR
It is found that Bcl9 depletion caused a pro-tumor effect of CAFs, while inhibition of abnormal activation of Wnt/β-catenin signal through BCL9 depletion benefited T-cell–mediated antitumor immune responses.
Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development
PDGF receptors in tumor biology: prognostic and predictive potential.
TLDR
Data suggest that continued characterization of PDGFR expression in human tumors should present opportunities for improved accuracy in prognosis and also allow novel biomarker-based clinical studies exploring the efficacy ofPDGFR-directed tumor therapies.
Cancer-Associated Fibroblasts Connect Metastasis-Promoting Communication in Colorectal Cancer
TLDR
This review applies the metastasis-promoting communication of colorectal CAFs to 10 cancer hallmarks described by Hanahan and Weinberg to re-explore the potential messages implicated in this process.
PDGF receptors in tumor stroma: Biological effects and associations with prognosis and response to treatment.
  • A. Östman
  • Medicine
    Advanced drug delivery reviews
  • 2017
Cancer-associated fibroblasts in digestive tumors.
TLDR
Increasing evidence has shown that spindle-shaped cancer-associated fibroblasts (CAFs) are a significant modifier of cancer evolution, and promote tumorigenesis, tumor invasion and metastasis by stimulating angiogenesis, malignant cell survival, epithelial-mesenchymal transition (EMT) and proliferation via direct cell-to-cell contact or secretion of soluble factors in most digestive solid tumors.
Stanniocalcin 1 in tumor microenvironment promotes metastasis of ovarian cancer
TLDR
The results revealed that STC1 promoted the phosphorylation of Akt (Ser473), and upregulated several epithelial–mesenchymal transition (EMT) markers including fibronectin，vimentin and slug, and demonstrated that STCs in tumor microenvironment could mediate the conversion of NFs to CAFs.
Snail1-expressing cancer-associated fibroblasts induce lung cancer cell epithelial-mesenchymal transition through miR-33b
TLDR
Understanding the molecular mechanism underlying the communication between stromal cells and tumor cells mediated by miR-33b may lead to the identification of novel targets for the treatment of lung cancer and understanding the role of Snail1 driving CAFs to induce lung cancer cell EMT may provide with a new perspective on the treatmentof lung cancer.
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