STATs Shape the Active Enhancer Landscape of T Cell Populations

  title={STATs Shape the Active Enhancer Landscape of T Cell Populations},
  author={Golnaz Vahedi and Hayato Takahashi and Shingo Nakayamada and Hong-wei Sun and Vittorio Sartorelli and Yuka Kanno and John J. O’Shea},
Signaling pathways are intimately involved in cellular differentiation, allowing cells to respond to their environment by regulating gene expression. Although enhancers are recognized as key elements that regulate selective gene expression, the interplay between signaling pathways and actively used enhancer elements is not clear. Here, we use CD4(+) T cells as a model of differentiation, mapping the activity of cell-type-specific enhancer elements in T helper 1 (Th1) and Th2 cells. Our data… CONTINUE READING
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