STAT6 polymorphisms are associated with neonatal regulatory T cells and cytokines and atopic diseases at 3 years.

@article{Casaca2013STAT6PA,
  title={STAT6 polymorphisms are associated with neonatal regulatory T cells and cytokines and atopic diseases at 3 years.},
  author={Vera Isabel Casaca and Sabina Illi and Elizabeth Klucker and Nikolaus Ballenberger and Michaela Schedel and Erika von Mutius and Michael Kabesch and Bianca Schaub},
  journal={Allergy},
  year={2013},
  volume={68 10},
  pages={1249-58}
}
BACKGROUND The transcription factor STAT6 is crucial for activation of the interleukin (IL)-4/IL-13 pathway and has been linked to regulatory T cells (Tregs). Associations of STAT6 polymorphisms with IgE levels were described; however, their impact on neonatal immune responses and early disease development is unknown. METHODS STAT6 polymorphisms were genotyped in cord blood mononuclear cells by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). Gene… CONTINUE READING
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Stat6 is required for mediating Allergy

  • MH Kaplan, U Schindler, ST Smiley, MJ. Grusby
  • Immunity
  • 2013

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