STAT6 is amplified in a subset of dedifferentiated liposarcoma

  title={STAT6 is amplified in a subset of dedifferentiated liposarcoma},
  author={Leona A. Doyle and Derrick Tao and Adri{\'a}n Mari{\~n}o-Enr{\'i}quez},
  journal={Modern Pathology},
A recurrent intrachromosomal rearrangement on chromosome 12q in solitary fibrous tumor leads to the formation of a NAB2–STAT6 fusion oncogene. As a result, nuclear expression of the cytoplasmic transcription factor STAT6 is found in solitary fibrous tumor and serves as a useful diagnostic marker. STAT6 is located in 12q13, a region containing well-characterized oncogenes that are commonly amplified in dedifferentiated liposarcoma; we have previously reported that STAT6 is expressed in a subset… CONTINUE READING
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