STAT6 expression in multiple cell types mediates the cooperative development of allergic airway disease.

@article{Chapoval2011STAT6EI,
  title={STAT6 expression in multiple cell types mediates the cooperative development of allergic airway disease.},
  author={Svetlana P Chapoval and Preeta Dasgupta and Elizabeth P. Smith and Louis J Detolla and Michael M. Lipsky and Ann E. Kelly-Welch and Achsah D. Keegan},
  journal={Journal of immunology},
  year={2011},
  volume={186 4},
  pages={2571-83}
}
Th2 cells induce asthma through the secretion of cytokines. Two such cytokines, IL-4 and IL-13, are critical mediators of many features of this disease. They both share a common receptor subunit, IL-4Rα, and signal through the STAT6 pathway. STAT6(-/-) mice have impaired Th2 differentiation and reduced airway response to allergen. Transferred Th2 cells were not able to elicit eosinophilia in response to OVA in STAT6(-/-) mice. To clarify the role of STAT6 in allergic airway inflammation, we… CONTINUE READING