STAT5a-targeting miRNA enhances chemosensitivity to cisplatin and 5-fluorouracil in human colorectal cancer cells.

@article{Hong2012STAT5atargetingME,
  title={STAT5a-targeting miRNA enhances chemosensitivity to cisplatin and 5-fluorouracil in human colorectal cancer cells.},
  author={Xuan Hong and Gong-yan Chen and Meng Wang and Changjie Lou and Yin-ling Mao and Zhiwei Li and Yanqiao Zhang},
  journal={Molecular medicine reports},
  year={2012},
  volume={5 5},
  pages={
          1215-9
        }
}
Signal transducers and activators of transcription 5 (STAT5) has been shown to be involved in a variety of cellular processes, including survival, proliferation, invasion, angiogenesis and immune evasion and is frequently overexpressed in human solid tumors and blood malignancies. The aim of this study was to investigate the role of STAT5a in colorectal cancer (CRC) progression. We inhibited the expression of STAT5a using lentivirus-mediated artificial microRNA (miRNA) interference in vitro and… 
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Construction of expression vector of siRNA specific for STAT5a and identification of its efficiency in MGC803 gastric cancer cell line
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It is shown in the experiment that STAT5a-specific siRNA could actively inhibitSTAT5a expression in mRNA level in MGC803 gastric cancer cel1 line, and decrease STAT5A protein expression.
Downregulation of myosin VI reduced cell growth and increased apoptosis in human colorectal cancer.
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MiR-124 and miR-506 inhibit progression and increase sensitivity to chemotherapy by targeting DNMT3B and DNMT1 in CRC and may provide novel avenues for the development of targeted therapies.
Involvement of STAT5 in Oncogenesis
TLDR
Since STAT5 contributes to tumour aggressiveness and cancer progression, inhibiting STAT5 constitutive activation in cancers that rely on its signalling makes for a promising targeted treatment option.
Exogenous bacterial DnaK increases protein kinases activity in human cancer cell lines
TLDR
The effect of exogenous Mycoplasma DnaK on kinases activity is investigated by treating in vitro four different eukaryotic cancer cell lines, namely lung and prostate cancer, colon adenocarcinoma, and neuroblastoma to provide a novel mechanism whereby components of the human microbiota and present in the tumor microenvironment are able to deregulate phosphorylation events during carcinogenesis and cancer progression.
Natural compounds to overcome cancer chemoresistance: toxicological and clinical issues
TLDR
This review provides an overview of the preclinical and clinical relevance of chemosensitization, giving special reference to curcumin (CUR) and sulforaphane (SFN) as agents to overcome apoptosis resistance against chemotherapy.
Investigating critical genes and gene interaction networks that mediate cyclophosphamide sensitivity in chronic myelogenous leukemia
TLDR
Several potential genes and pathways contributing to cyclophosphamide resistance are identified, and the involvement of STAT5A and S100A4 in drug resistance is confirmed, enabling improved understanding of the mechanisms underlying drug resistance in CML cells.
Unique protein expression signatures of survival time in kidney renal clear cell carcinoma through a pan-cancer screening
TLDR
This study systematically investigated KIRC’s prognostic biomarkers for survival using the reverse phase protein array (RPPA) data and the high throughput sequencing data from The Cancer Genome Atlas (TCGA), finding that many protein biomarkers were prognostic for patients’ survival in KIRC.
Cytokine regulation of mammary gland development and epithelial cell functions through discrete activities of Stat proteins
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