STAT5 outcompetes STAT3 to regulate the expression of the oncogenic transcriptional modulator BCL6.

@article{Walker2013STAT5OS,
  title={STAT5 outcompetes STAT3 to regulate the expression of the oncogenic transcriptional modulator BCL6.},
  author={Scott Raymond Walker and Erik A. Nelson and Jennifer E. Yeh and Luca Pinello and Guo-Cheng Yuan and David Michael Frank},
  journal={Molecular and cellular biology},
  year={2013},
  volume={33 15},
  pages={
          2879-90
        }
}
Inappropriate activation of the transcription factors STAT3 and STAT5 has been shown to drive cancer pathogenesis through dysregulation of genes involved in cell survival, growth, and differentiation. Although STAT3 and STAT5 are structurally related, they can have opposite effects on key genes, including BCL6. BCL6, a transcriptional repressor, has been shown to be oncogenic in diffuse large B cell lymphoma. BCL6 also plays an important role in breast cancer pathogenesis, a disease in which… CONTINUE READING
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