STAT5 in B cell development and leukemia.

  title={STAT5 in B cell development and leukemia.},
  author={Stephen Malin and Shane McManus and Meinrad Busslinger},
  journal={Current opinion in immunology},
  volume={22 2},
Early B cell development depends on a network of transcription factors, whereby E2A and EBF1 regulate B cell specification and Pax5 controls B-lineage commitment. In contrast, activation of the transcription factor STAT5 in response to IL-7R signaling promotes cell survival by activating the prosurvival gene Mcl1 and orders immunoglobulin gene rearrangement by repressing Igk recombination in pro-B cells. Subsequently, it cooperates with the pre-B cell receptor to facilitate pre-B cell expansion… CONTINUE READING
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