STAT3 tyrosine phosphorylation influences survival in glioblastoma

  title={STAT3 tyrosine phosphorylation influences survival in glioblastoma},
  author={Peter Birner and Kalina Toumangelova-Uzeir and Sevdalin Natchev and Marin Guentchev},
  journal={Journal of Neuro-Oncology},
Signal transducer and activator of transcription protein 3 (STAT3) is a regulator of central nervous system (CNS) development and a promising therapeutic target in human cancers. Activation of STAT3 promotes oncogenesis in a variety of tissues, but knowledge of its role in glioblastoma is still limited. Recent results indicate that STAT3 acts as a tumor suppressor or an oncogene depending upon the genetic background of the tumor. Here we immunohistochemically assessed Y705-phosphorylated STAT3… CONTINUE READING


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Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

N de la Iglesia, G Konopka, SV Puram
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