STAT3 modulates cigarette smoke-induced inflammation and protease expression

@inproceedings{Geraghty2013STAT3MC,
  title={STAT3 modulates cigarette smoke-induced inflammation and protease expression},
  author={Patrick Geraghty and A Elizabeth Wyman and Itsaso Garc{\'i}a-Arcos and Abdoulaye Jules Dabo and Sonya Gadhvi and Robert F Foronjy},
  booktitle={Front. Physiol.},
  year={2013}
}
Signal transducer and activator of transcription-3 (STAT3) regulates inflammation, apoptosis, and protease expression, which are critical processes associated with airway injury and lung tissue destruction. However, the precise role of STAT3 in the development of airway diseases such as chronic obstructive pulmonary disease (COPD) has not been established. This study shows that cigarette smoke activates STAT3 in the lungs of mice. Since cigarette smoke activated STAT3 in the lung, we then… CONTINUE READING
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Physiology, a section of the journal Frontiers in Physiology

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2 Excerpts

STAT3 modulates cigarette smoke-induced inflammation and protease expression

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