STAT3 mediates oncogenic addiction to TEL-AML1 in t(12;21) acute lymphoblastic leukemia.

@article{Mangolini2013STAT3MO,
  title={STAT3 mediates oncogenic addiction to TEL-AML1 in t(12;21) acute lymphoblastic leukemia.},
  author={Maurizio Mangolini and Jasper de Boer and Vanessa Walf-Vorderw{\"u}lbecke and Rs Roel Pieters and Monique L den Boer and Owen T. Williams},
  journal={Blood},
  year={2013},
  volume={122 4},
  pages={
          542-9
        }
}
The t(12;21)(p13;q22) translocation is the most common chromosomal abnormality in pediatric leukemia. Although this rearrangement involves 2 well-characterized transcription factors, TEL and AML1, the molecular pathways affected by the result of the translocation remain largely unknown. Also in light of recent studies showing genetic and functional heterogeneities in cells responsible for cancer clone maintenance and propagation, targeting a single common deregulated pathway may be critical for… CONTINUE READING
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